Ex-Smokers' Lung Cell Regeneration

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Ex-Smokers' Lung Cell Regeneration

#1  Postby Spearthrower » Jan 29, 2020 9:09 pm

https://www.nature.com/articles/s41586-020-1961-1

Tobacco smoking and somatic mutations in human bronchial epithelium

Kenichi Yoshida et al (2020)

Tobacco smoking causes lung cancer1,2,3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6,7,8,9,10, but equivalent data for normal bronchial cells are lacking. Here we sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking was the major influence on mutational burden, typically adding from 1,000 to 10,000 mutations per cell; massively increasing the variance both within and between subjects; and generating several distinct mutational signatures of substitutions and of insertions and deletions. A population of cells in individuals with a history of smoking had mutational burdens that were equivalent to those expected for people who had never smoked: these cells had less damage from tobacco-specific mutational processes, were fourfold more frequent in ex-smokers than current smokers and had considerably longer telomeres than their more-mutated counterparts. Driver mutations increased in frequency with age, affecting 4–14% of cells in middle-aged subjects who had never smoked. In current smokers, at least 25% of cells carried driver mutations and 0–6% of cells had two or even three drivers. Thus, tobacco smoking increases mutational burden, cell-to-cell heterogeneity and driver mutations, but quitting promotes replenishment of the bronchial epithelium from mitotically quiescent cells that have avoided tobacco mutagenesis.



Encouragement for those looking to quit smoking.
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Re: Ex-Smokers' Lung Cell Regeneration

#2  Postby campermon » Jan 29, 2020 9:33 pm

Best thing I ever did was to quit smoking. Went from wheezy wimp to cycling 100 mile charity ride last May.

:thumbup:
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Re: Ex-Smokers' Lung Cell Regeneration

#3  Postby scott1328 » Jan 29, 2020 9:38 pm

Spearthrower wrote:https://www.nature.com/articles/s41586-020-1961-1

Tobacco smoking and somatic mutations in human bronchial epithelium

Kenichi Yoshida et al (2020)

Tobacco smoking causes lung cancer1,2,3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6,7,8,9,10, but equivalent data for normal bronchial cells are lacking. Here we sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking was the major influence on mutational burden, typically adding from 1,000 to 10,000 mutations per cell; massively increasing the variance both within and between subjects; and generating several distinct mutational signatures of substitutions and of insertions and deletions. A population of cells in individuals with a history of smoking had mutational burdens that were equivalent to those expected for people who had never smoked: these cells had less damage from tobacco-specific mutational processes, were fourfold more frequent in ex-smokers than current smokers and had considerably longer telomeres than their more-mutated counterparts. Driver mutations increased in frequency with age, affecting 4–14% of cells in middle-aged subjects who had never smoked. In current smokers, at least 25% of cells carried driver mutations and 0–6% of cells had two or even three drivers. Thus, tobacco smoking increases mutational burden, cell-to-cell heterogeneity and driver mutations, but quitting promotes replenishment of the bronchial epithelium from mitotically quiescent cells that have avoided tobacco mutagenesis.



Encouragement for those looking to quit smoking.

So Daily Mail short version of this is ex-smokers have healthier lungs than non-smokers!
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Re: Ex-Smokers' Lung Cell Regeneration

#4  Postby Spearthrower » Jan 30, 2020 5:08 am

scott1328 wrote:
So Daily Mail short version of this is ex-smokers have healthier lungs than non-smokers!



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Re: Ex-Smokers' Lung Cell Regeneration

#5  Postby Keep It Real » Jan 30, 2020 5:44 am

A very good-hearted thread Spearthrower, props. I'm now 30 days nicotine/tobacco free. Onto the next challenge I say :work:
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Re: Ex-Smokers' Lung Cell Regeneration

#6  Postby Alan B » Jan 30, 2020 1:40 pm

I reckon I'm OK. I packed up 64 years ago...
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Re: Ex-Smokers' Lung Cell Regeneration

#7  Postby Keep It Real » Jan 30, 2020 10:01 pm

You gave up when you were 19? Roflyroflcopter TBH mate.
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Re: Ex-Smokers' Lung Cell Regeneration

#8  Postby Keep It Real » Jan 31, 2020 11:23 pm

OK Hermit my esteemed elder, in many regards. Allen Carr has the truth technique...accountants, I don't know, accountants are boring no? Shallow grave?
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Re: Ex-Smokers' Lung Cell Regeneration

#9  Postby Hermit » Jan 31, 2020 11:34 pm

Keep It Real wrote:OK Hermit my esteemed elder, in many regards. Allen Carr has the truth technique...accountants, I don't know, accountants are boring no? Shallow grave?
Allen Carr made his money from telling smokers how easy it is to kick the nicotine addiction. He gave up smoking when he was 48 and died 25 years later - of lung cancer.

His talking cure might be what you call "the truth technique" for some. It didn't work for me.
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Re: Ex-Smokers' Lung Cell Regeneration

#10  Postby Keep It Real » Jan 31, 2020 11:39 pm

Allen Carr's "easy way" has SINGLE HANDEDLY enabled me to stop smoking. I virtually will hear no word against him..flounce :jokes: ; )
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Re: Ex-Smokers' Lung Cell Regeneration

#11  Postby Blip » Feb 01, 2020 11:02 am


!
GENERAL MODNOTE
This thread is about ex-smokers' lung cell regeneration and the encouragement that may give to former smokers or those seeking to quit. Please stick to that topic.

A series of posts has been sent to a more appropriate home here.
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Re: Ex-Smokers' Lung Cell Regeneration

#12  Postby Alan B » Feb 01, 2020 11:25 am

Keep It Real wrote:You gave up when you were 19? Roflyroflcopter TBH mate.


My mistake. It was 58 years ago when I was 25. (It's me age y'know...).

I was having a fag and put it down on the table while I was busy when I noticed it was burning into the table. Fuck it. What's the point. So I gave up.
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Re: Ex-Smokers' Lung Cell Regeneration

#13  Postby Svartalf » Feb 01, 2020 10:35 pm

who cares how former smokers recover from the habit, I never smoked at all, and thanks to a tenacious bronchitis, I'm still coughing and weak for the third week in a row, starting on the fourth.
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Re: Ex-Smokers' Lung Cell Regeneration

#14  Postby Keep It Real » Feb 01, 2020 11:27 pm

Hermit wrote:
Keep It Real wrote:OK Hermit my esteemed elder, in many regards. Allen Carr has the truth technique...accountants, I don't know, accountants are boring no? Shallow grave?
Allen Carr made his money from telling smokers how easy it is to kick the nicotine addiction. He gave up smoking when he was 48 and died 25 years later - of lung cancer.

His talking cure might be what you call "the truth technique" for some. It didn't work for me.


I think the audio book superior to the text version, probs as it is manifestly a personified "talking cure" and so appeals to my notions regarding therapeutic techniques. It has also likely gone through several revisions since you (last?) tried it. I listened to the whole thing in one day, 6.5 hours and made abt 5 sides of A4 notes to drill the message(s) and truths home. I had one "slip up" since then, due to cigars opening the door by my mind, but then dipped back into the book, set a new (salient) quit date (Jan 1) and am now 32 days zero nicotine and feeling joyful still at having seen the back of the filthy bastard things. 3c
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Re: Ex-Smokers' Lung Cell Regeneration

#15  Postby Spearthrower » Feb 02, 2020 7:42 am

Svartalf wrote:who cares how former smokers recover from the habit, ...


Smokers.
Smokers' families.
Former smokers.
Former smokers' families.
Medical practitioners who have to deal with lung cancer.
Tax-payers in societies with universal health-care.
Human beings with entry level compassion for their fellows.


Who doesn't care?

Would-be edgelords.
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Re: Ex-Smokers' Lung Cell Regeneration

#16  Postby Keep It Real » Feb 02, 2020 11:23 pm

RE Allen Carr, from wiki :

Carr wrote to Tony Blair, urging the UK Government and NHS to accept his method, saying that the "powerful influence" of lobbyists working for nicotine replacement firms had turned them against him.


I'd bet my left hand Mr Carr didn't ask for a penny in remuneration, had Easy Way been taken up by the NHS.

Sometimes, it would appear all too often, money truly is the root of all evil.
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