Treatment for Alzheimers

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Understanding the basis and treatment of disease.

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Treatment for Alzheimers

#1  Postby Spearthrower » Nov 30, 2022 2:53 am

https://www.nejm.org/doi/full/10.1056/NEJMoa2212948

Background

The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with early Alzheimer’s disease.

...

Conclusions

Lecanemab reduced markers of amyloid in early Alzheimer’s disease and resulted in moderately less decline on measures of cognition and function than placebo at 18 months but was associated with adverse events. Longer trials are warranted to determine the efficacy and safety of lecanemab in early Alzheimer’s disease.



So it's still a long way from being a very effective treatment of Alzheimer's but it's the first time anyone's got a handle on it at all.

It destroys the amyloid protein that collects between neurons forming the distinctive plaque that causes the pathologies and symptoms of Alzheimer's.

This is no silver bullet though as it works most effectively at the onset of Alzheimer's and that can be tricky to diagnose, the efficacy is slight, perhaps staving off cognitive impairment by months, and has a number of quite serious potential side effects like brain bleeds, but it's an actual step forward in treating this horrible life-ending disease.
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