asyncritus wrote:Let's start with MUTATIONS.
What's a mutation? Answer: a change of the nucleotide sequence of the genome of an organism
The vast majority of mutations are either harmful or neutral in their effects. Offhand I cannot recall an improvement created by a mutation. Hence wiki:
One study on genetic variations between different species of Drosophila suggests that if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms having damaging effects, and the remainder being either neutral or weakly beneficial.[4] Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent mutations.[1]
Yes, mutations in protein coding genes are likely to be either nearly neutral or slightly deleterious for the most part. Beneficial mutations can happen but they are rare. Of course, it's an average because every protein is different.
Of course, our genomes contain a lot more than just protein coding sequence. Most of it is junk, a smaller part is non-coding regulatory regions, and then a tiny fraction is protein coding genes.
Also, mutations are different. You can have a duplication of a protein coding gene, which doesn't alter the protein, but it's expression levels instead. This is what has happened to the salivary amylase gene in humans. Some people have many copies of this gene, and it has been demonstrably beneficial in dealing with a high-starch diet.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377015/Diet and the evolution of human amylase gene copy number variation Abstract
Starch consumption is a prominent characteristic of agricultural societies and hunter-gatherers in arid environments. In contrast, rainforest and circum-arctic hunter-gatherers and some pastoralists consume much less starch1-3. This behavioral variation raises the possibility that different selective pressures have acted on amylase, the enzyme responsible for starch hydrolysis4. We found that salivary amylase gene (AMY1) copy number is correlated positively with salivary amylase protein levels, and that individuals from populations with high-starch diets have on average more AMY1 copies than those with traditionally low-starch diets. Comparisons with other loci in a subset of these populations suggest that the level of AMY1 copy number differentiation is unusual. This example of positive selection on a copy number variable gene is one of the first in the human genome. Higher AMY1 copy numbers and protein levels likely improve the digestion of starchy foods, and may buffer against the fitness-reducing effects of intestinal disease.
So there you have it, you have now been told of an example of a beneficial mutation, and you now no longer at any point in your life have to feign ignorance and memory loss when talking about whether beneficial mutations can happen. Save the link.
asyncritus wrote:Let us then hypothesise a proto-swallow (in Goya, Argentina) which remains locally and does not migrate, or only does so to a very limited extent. Its genome is stable, and totally functional.
Fast forward to its descendants, migrating swallows capable of flying to Capistrano from Goya, a one way journey of 7,500 miles, and back 6 mths later. These swallows can pass on the genetic information needed for the bird to make that migration, which we have to assume is in the genome somewhere
No, technically it doesn't. What only needs to be there in an otherwise already migrating species, is the instinctive behavior to "start migrating" when certain environmental clues accumulate (food scarcity, shorter days with more darkness, colder).
Now the brain becomes important in conjunction with the navigational equipment. That means the birds senses. Birds use all sorts of envionmental clues when navigating, among which is the ability to navigate using the earth's magnetic field. I suggest you watch this video:
[youtube]http://www.youtube.com/watch?v=wwgQVZju1ZM[/youtube]
asyncritus wrote:The question which needs a satisfactory answeris: how did that information enter the genome?
The specific information you're asking for doesn't need to be in the genome at all. Already migrating birds could suffer mutations that would alter their direction of migration, by changing their sensitivity to various envionmental clues, resulting in the swallows starting a new migration route and ending up somewhere else. They don't need to have information about the entire landscape of the trip encoded in their genes, they only need to respond somewhat predictably to certain cues they meet along the way.
Fuck, we already know they do this, since they apparently stopped going to church in Capistrano and started making nests elsewhere.
The whole bullshit about them arriving on exact dates every year, was probably bullshit to begin with, and instead people started celebrating the bird's return on specific dates instead. But in actuality, they probably arrive incrementally over a couple of days. I'm going to go out on a limp and guess that if you really bothered to check how many arrive and with what frequency, you'll get a nice standard distribution spread out over 3-5 days. That's how nature normally works.
asyncritus wrote:If mutations are as damaging as the above quote from wiki demonstrates, then is it likely that such a massive reconstruction in the bird's genome could come about by 'mutation'?
You're entirely without basis assuming that changes in their migration patterns requires "massive reconstruction" of their genomes. There's nothing to support this assumption, it's borne out entirely of your ignorance of animal behavior and genetics. I suggest you remedy this lack by getting some proper biology education.
Also, you're overemphasizing the nature of mutations and their effect on the genomes of organisms. Most of the variation in sexually breeding populations actually come from genetic recombination. We might not even need to appeal mutation-borne variation to explain changes in migration patterns of birds, but simply to the chance products of sexual recombination.
asyncritus wrote:What effects would the 'mutations' have to produce?
If we absolutely insist that we must stick to mutations, it depends. There are many kinds of mutations. One could go down millions of routes of speculation. Heck, a single mutation could change the bird's sensitivity to the strength of the magnetic field of the planet, causing it to migrate much further. The bird would retain all it's other instinctive behaviors, like where and when to rest, what cues to look for and seek out when it migrates and so on. That's just
one way it could happen.
asyncritus wrote:1 The geographical information would have to be inserted correctly. A one degree west error would mean extinction.
Not really, no.
asyncritus wrote:2 The timing would have to be inserted as well, somehow, to get them there on or around 18th March.
Already covered.
1. No reason to believe they really start migrating on the exact same date every year.
2. Seasonal accumulations of environmental clues could spur them to start migrating.
3. They would usually arrive in a pattern spread out over a period of time, which would probably end up looking like a normal distribution.
asyncritus wrote:3 The bird's strength would have to be increased dramatically, to power that enormous flight
For all we know the bird was already this strong before it migrated all the way. Or, it could also be the case that the bird migrated in increments and ended up with the entire distance they migrate today. If that was the case, there would be plenty of opportunity for natural selection to hone the bird's physique.
asyncritus wrote:4 Anything else?
It's your list, you tell me.
asyncritus wrote:So the mutations alone are most improbable to produce such an enormous behaviour change, not to mention the accuracy of the flight path.
Already dealt with, your assumptions about mutations and about what kind of information needs to be in the genomes of living organisms is at fault. I don't need to have a complete picture of Denmark to know how to get to the nearest train station. My environment contains certain cues, like noise from trains and roadsigns.
For the bird, this could be analogous to seeking out specific magnetic field line angles, specific forests and mountains or whatever other cues the bird uses to navigate. It finds them attractive and flys towards/along them. It doesn't even need to know how or why. This behavior could be partially instictive, partially learned.
asyncritus wrote:Where natural selection would fit in to all this, I do not know.
At least you're being honest.
asyncritus wrote:But I'm sure you can see the problems, and the reason for my questions.
Yes and I prescribe you a healthy dose of evolutionary genetics, biophysics and ethology to remedy this.