Nother Alzheimers treatment looks good

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Nother Alzheimers treatment looks good

#1  Postby Macdoc » Nov 03, 2016 1:29 am

Alzheimer's treatment within reach after successful drug trial
Tablet that ‘switches off’ production of toxic amyloid proteins could be first treatment licensed in a decade if it is also shown to slow mental decline


https://www.theguardian.com/society/201 ... ques-bace1

nother one as well...just in time for me... :mrgreen: :mrgreen: :coffee:

Trial shows tantalising signs that new Alzheimer's drug could benefit early-stage patients
Injections of the antibody aducanumab appear to slow condition in patients at earliest stages of disease, raising hopes for treatment

https://www.theguardian.com/science/201 ... aducanumab
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Re: Nother Alzheimers treatment looks good

#2  Postby DavidMcC » Jan 18, 2017 1:31 pm

Hmm... I wonder what BACE1 evolved for, then? Presumably not just to create plaque.

EDIT: At first, I thought: who's this "Nother" guy. Then the penny dropped.
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Re: Nother Alzheimers treatment looks good

#3  Postby DavidMcC » Jan 18, 2017 2:26 pm

... OK, it seems we're looking at an unfortunate (folding) variant of an otherwise useful enzyme:
http://www.origene.com/protein/TP309115/BACE1.aspx?gclid=CJHNiuzsy9ECFckaGwodt-kDkQ
Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.

EDIT: I have modified the first line, to remove the word,"gene", since it is the (indirect) gene product that may fold badly, not the gene itself!
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Re: Nother Alzheimers treatment looks good

#4  Postby CdesignProponentsist » Jan 19, 2017 7:01 pm

Dementia runs in my father's family so I'm always happy to see advancements like this.
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Re: Nother Alzheimers treatment looks good

#5  Postby DavidMcC » Jan 20, 2017 12:51 pm

CdesignProponentsist wrote:Dementia runs in my father's family so I'm always happy to see advancements like this.

Me too, although it didn't set in until he was very old. He died aged 81 of kidney failure, but he was a helpless cabbage for several years before that, due to the dementia.
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