Prostate Cancer, a 'Cure'?

Massive doses of Testosterone 'Shock Cancer to Death'.

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Prostate Cancer, a 'Cure'?

#1  Postby Alan B » Dec 07, 2016 2:24 pm

Telegraph
Man 'cured' of prostate cancer after doctors shock tumour to death with testosterone

A man with advanced prostate cancer is believed to be cured after doctors 'shocked' his tumour to death with huge amounts of testosterone.
The result has been described as 'unexpected' and 'exciting' because most prostate cancer therapies work by depriving tumours of testosterone, because cancer uses it as a fuel.
Other seriously ill men taking part in the same trial showed responses that astounded scientists, with tumours shrinking and the progress of their disease halted.
Levels of Prostate Specific Antigen (PSA), a blood marker used to monitor prostate cancer, also fell in the majority of the 47 participants.
One individual whose PSA levels dropped to zero after three months and shows no remaining trace of the disease after 22 cycles of treatment appears to be cured, said the researchers.
Professor Sam Denmeade, from Johns Hopkins University School of Medicine in Baltimore, US, who led the study, said: ""Our goal is to shock the cancer cells by exposing them rapidly to very high followed by very low levels of testosterone in the blood. The results are unexpected and exciting.
"We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer.
"Many of the men have stable disease that has not progressed for more than 12 months.
"I think we may have cured one man whose PSA dropped to zero after three months and has remained so now for 22 cycles. His disease has all disappeared."
...
"Many exciting new lines of attack against prostate cancer are emerging of which this is one.
"However, this is early stage research and further studies are needed in order to understand exactly how intriguing developments like this work and to test the findings more robustly in large clinical trials."

The Express
Scientists have been surprised by the results of the trial - as the male hormone is generally assumed to fuel cancer.
Tumours were seen to shrink and in several patients also suffering with the cancer, the progress of the tumours slowed down and even stopped.
Levels of Prostate Specific Antigen (PSA), a marker used to monitor prostate cancer, fell in the majority of the 47 participants.
One individual whose PSA levels dropped to zero after three months and shows no remaining trace of the disease after 22 cycles of treatment appears to be cured, said the researchers.
Professor Sam Denmeade, from Johns Hopkins University School of Medicine in Baltimore, US, who led the new study, described the results as ‘unexpected and exciting’.
"We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer,” he said.
"Thus far we have observed dramatic PSA response in a subset of men; PSA levels declined in about 40 per cent of men and in about 30 per cent of men levels fell by more than 50 per cent.
"Some men also have objective responses with a decrease in the size of measurable disease, mostly in lymph nodes. Many of the men have stable disease that has not progressed for more than 12 months.

Very encouraging news. Now, if this can be repeated with other studies of this treatment...

I am due to see the specialist in March and I will certainly bring this study to his attention.
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Re: Prostate Cancer, a 'Cure'?

#2  Postby Rachel Bronwyn » Dec 07, 2016 2:49 pm

Other prostate cancers grow in the presence of testosterone and treatment involves chemical castration. Different tumour, different treatment.
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Re: Prostate Cancer, a 'Cure'?

#3  Postby Alan B » Dec 07, 2016 3:03 pm

Only at the levels produced by the testes. If it is 'over-fed' then it would appear to 'choke it to death' (so it would seem).

Edit
Typical media - this study is about 23 months old: "no news, let's drag up something old..."

Here is the earlier report:
News-Medical 8 Jan 2015

Edit. Ariffmatik cock-up.
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Re: Prostate Cancer, a 'Cure'?

#4  Postby Alan B » Dec 20, 2016 11:13 am

This seems to be a real step forward.
The Guardian
Laser-activated drug a 'leap forward' for prostate cancer treatment

A drug activated by laser light successfully destroys early prostate cancer while avoiding side-effects that commonly occur with surgery, trial results have shown.

The new technique, called vascular-targeted photodynamic therapy (VTP), involves injecting a light-sensitive drug into the bloodstream. The drug is then “switched on” by laser pulses fired through optical fibres inserted into the prostate.

Of 196 men who received the treatment, about half showed no signs of the disease two years later, compared with 13.5% of those given standard care.
Because VTP targets only prostate tumours, it does not cause the long-term problems of impotence and urinary incontinence often associated with “radical” surgery or radiotherapy.

Lead investigator Professor Mark Emberton, consultant urologist at University College London hospital, said: “These results are excellent news for men with early localised prostate cancer, offering a treatment that can kill cancer without removing or destroying the prostate.

“This is truly a huge leap forward for prostate cancer treatment, which has previously lagged decades behind other solid cancers such as breast cancer.

“In 1975, almost everyone with breast cancer was given a radical mastectomy, but since then treatments have steady improved and we now rarely need to remove the whole breast.

“In prostate cancer, we are still commonly removing or irradiating the whole prostate, so the success of this new tissue-preserving treatment is welcome news indeed.”
...
The trial, reported in the Lancet Oncology journal, was conducted across 47 treatment sites in 10 European countries, most of which were performing VTP for the first time.

Emberton said: “The fact that the treatment was performed so successfully by non-specialist centres in various health systems is really remarkable.

“New procedures are generally associated with a learning curve, but the lack of complications in the trial suggests that the treatment protocol is safe, efficient and relatively easy to scale up.

“We would also expect the treatment to be far more precise if we repeated it today, as technology has come a long way since the study began in 2011.

“We can now pinpoint prostate cancers using MRI (magnetic resonance imaging) scans and targeted biopsies, allowing a much more targeted approach to diagnosis and treatment.

“This means we could accurately identify men who would benefit from VTP and deliver treatment more precisely to the tumour.


A more in-depth report.
BBC
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