Posted: Apr 14, 2010 12:43 pm
Rumraket wrote:rainbow wrote:Preparative synthesis of 2-aminooxazole 11 using phosphate catalysis
To a solution of glycolaldehyde 10 (1.2 g, 20 mmol) in sodium hydrogen phosphate
buffer (1.0M, 10 mL, pH = 7.0) was added cyanamide 8 (840 mg, 20 mmol). The
solution was stirred at 60°C for 3 h, cooled to r.t., and extracted with EtOAc (5 × 20
mL). The combined EtOAc extracts were concentrated in vacuo to give 2-
aminooxazole 11 (1.2 g, 75%) as a white powder.
Now besides the problematic concentrations, pH and temperatures, has anybody got an idea how a vacuum pump got to be there in the PreBiotic Earth?
The vacuum is a step in the preparation for analysis, not the actual reaction.
And Rainbow has not even remotely shown that there is anything 'problematic' about the concentrations, pH or temperatures.
We await his evidence.