Posted: Jan 29, 2016 7:00 pm
by Rachel Bronwyn
What the hell am in forgetting from first year that's preventing me from helping a student with this question?

I feel like such an asshole.

Determine the relative ratio of all four ionic species of histidine at pH 1.8. 1.8 just so happens to be pKa1....

The [A-/HA] for forms A/B, B/C and C/D at pH 1.8 are: 1, 6.31e-5 and 3.16e-8.

Given that 1.8 is pKa1, how the hell does one go from three A-/HA concentrations to a relative ratio of the concentrations of all four ionic species at this pH?