Posted: Nov 14, 2017 2:20 pm
Oldskeptic wrote:Oldskeptic wrote:Marilyn A. Huesti, Neuroscience, Xenobiology, Physiology
BS, MS, PhD, MD wrote:
Perez-Reyes et al. described the efficacy of five different vehicles for oral administration of THC in gelatin capsules [26]. Glycocholate and sesame oil improved the bioavailability of oral THC; however, there was considerable variability in peak concentrations and rates of absorption, even when the drug was administered in the same vehicle. Oral THC bioavailability was reported to be 10−20% by Wall et al. [27]. Participants were dosed with either 15 mg (women) or 20 mg (men) of THC dissolved in sesame oil and contained in gelatin capsules. THC Plasma concentrations peaked ca. 4−6 h after ingestion of 15−20 mg of THC in sesame oil. A percentage of the THC was radiolabeled; however, investigators were unable to differentiate labeled THC from its labeled metabolites. Thus, THC concentrations were overestimated.
Possibly a more accurate assessment of oral bioavailability of THC in plasma samples was reported by Ohlsson et al., based on GC/MS experiments [5]. The peak THC concentrations ranged from 4.4 to 11 ng/ml, occurring 1−5 h following ingestion of 20 mg of THC in a chocolate cookie; the oral bioavailability was estimated to be 6%. Slow rates of absorption and low THC concentrations occur after oral administration of THC or cannabis. Several factors may account for the low oral bioavailability of 4−20% (as compared to intravenous drug administration), including variable absorption, degradation of drug in the stomach, and significant first-pass metabolism to active 11-OH-THC and inactive metabolites in the liver.
Add to that that CBD has even less bioavailibility than THC and what you come up with with edibles is a big waste of money.
Just curious Piper, did that help clear anything up for you? If you want the full medicinal effects of cannabis you have to vape it, smoke, or shoot it. That's it.
I'd like to add that knowing your threshold for ingested cannabis is impossible until you go past it because unlike vaped or smoked cannabis ingested takes an hour or so to kick in. And if you've pushed it a bit too far it's possible that you're in for 4 or 5 hours of a hellish paranoid infused experience.
So, in my experience, and opinion, with edibles you're just wasting your money or flirting with disaster.
I read some of it, but it's too specialized for me to really understand. I did notice in one section that the bioavailability for inhaled was 2%-56&, whereas for ingested was 4%-20%.
But me, like many other medicinal patients, if I can't eat it, I shouldn't use it. I have respiratory problems, and smoking pot no doubt exacerbated them.
Each person will have different bioavailabilities. And it's different at different times and under different conditions. The biggest drawback to edibles is controlling the dose, that's not readily easy like smoking is.
I get stoned every day from eating it, and some of these highs are much more intense than when I smoked enough every day to tranquilize an elephant...seal.
It also lasts longer, both the high and the supply.
The side effects that are the medicinal benefits are much more noticeable from eating it. Unfortunately I'd probably be about 20 pounds lighter if I still smoked it. I never used to get the munchies, but from eating it I do.