Posted: Dec 20, 2014 7:58 am
BooBoo wrote:Shrunk wrote:
And Summers' paper confirms that. So they were right.
No, the paper does not state that at all. It confirms that two mutations are necessary and, crucially, that "the mutations be added in a specific order to avoid decreases in chloroquine transport." The paper also admits that there would be "significant transient reductions in CQ transport activity before the full complement of Dd2 mutations is attained. The authors, however, speculate that a compensatory change could allow deleterious changes to be masked/buffered: "one or more compensatory changes (e.g., perhaps R371I and/or M74I) could arise at an early stage to maintain the normal physiological function of the protein while it develops the ability to transport CQ."
And therefore God?
Show the rest of the workings if you would.