Posted: Oct 25, 2016 6:41 am
by Pebble
Vermeulen J. wrote:

Chemo toxins are about the only kind of 'medicine' that isn't tested against placebo's (because chemo has severe side effects which would immediately distinguish the placebo group from the group of patients getting the real thing poison). Also, because of the medical dogma that 'cancer rarely goes away by itself'....

No such assumption is necessary. It is simply sufficient to know the average rate of progression/regression and the timeline to a pre-specified mortality say 20 or 50%. There is no need to worry about the odd outlier, since they cannot materially affect ones ability to distinguish between interventions of different efficacy. Second the push to avoid placebo controls came from patients organisations. It is perfectly possible to do DBRCTs in cancer - simply adding one therapy at a time to a base therapy. If of course you want to go back to how it was in the 50s and 60s before chemotherapy I suggest you read a little medical history before advising that. Yes in the days before double blind trials is when the first treatments were developed. After you have read some history, perhaps you may understand why we do not wish to do placebo controlled trials of parachutes at this juncture - even though no one ever did them.