Posted: Feb 26, 2019 3:50 pm
by lpetrich
The authors used:

KEGG Database

KEGG (Kyoto Encyclopedia of Genes and Genomes) is a database resource that integrates genomic, chemical and systemic functional information. In particular, gene catalogs from completely sequenced genomes are linked to higher-level systemic functions of the cell, the organism and the ecosystem.

LUCApedia

LUCApedia is a unified framework containing multiple datasets related to the Last Universal Common Ancestor (LUCA) and its predecessors. The database can be searched by protein name or Uniprot ID. Text and MySQL datafiles are also available on the download page.

eQuilibrator: The Biochemical Thermodynamics Calculator
One can input reactions like glucose ⇌ 2 ethanol + 2 CO2 , compounds like ATP , and enzymes like rubisco .


This has implications for how common the origin of life might be. It is evident from this research and a lot of other research that Earth life bears the stamp of origin in a hydrothermal vent. It also suggests that RNA may be one of several possible replacements and elaborations that the original replicator might have had.