Posted: Jan 18, 2017 2:26 pm
... OK, it seems we're looking at an unfortunate (folding) variant of an otherwise useful enzyme:
http://www.origene.com/protein/TP309115/BACE1.aspx?gclid=CJHNiuzsy9ECFckaGwodt-kDkQ
EDIT: I have modified the first line, to remove the word,"gene", since it is the (indirect) gene product that may fold badly, not the gene itself!
http://www.origene.com/protein/TP309115/BACE1.aspx?gclid=CJHNiuzsy9ECFckaGwodt-kDkQ
Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
EDIT: I have modified the first line, to remove the word,"gene", since it is the (indirect) gene product that may fold badly, not the gene itself!