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Both the writing and artwork in 100 Bullets exemplifies the noir and pulp genres of popular modern fiction. It presents morally ambiguous stories with dark realism. Consistent with noir convention, most of the characters are deeply flawed.[2] As is also quite common in such genres, 100 Bullets frequently portrays stylized and graphic violence.

100 Bullets is notable for creator/writer Brian Azzarello's realistic use of regional and local dialects/accents, as well as the frequent, sometimes dense use of slang and oblique, metaphorical language in his characters' dialogue.

While initially presented as an episodic series of self-contained storylines, 100 Bullets eventually becomes a sprawling crime saga that embraces a sense that everyone and everything is connected.
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Plot

The initial plot of 100 Bullets hinges on the question of whether people would take the chance to get away with revenge. The mysterious Agent Graves approaches someone who has been the victim of a terrible wrong. Graves gives them the chance to set things right by providing them a handgun, the eponymous 100 bullets, and documentation of the person primarily and personally responsible for the recipient's woes. He informs the candidate that the bullets are completely untraceable, and any law enforcement investigation that uncovers one of these bullets will immediately stop.