Progress in learning about and fighting Alzheimer's

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Progress in learning about and fighting Alzheimer's

#1  Postby kennyc » Dec 23, 2013 1:27 pm

Where Alzheimer's Starts and How It Spreads

Dec. 22, 2013 — Using high-resolution functional MRI (fMRI) imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center (CUMC) researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease, when drugs may be most effective. The study was published today in the online edition of the journal Nature Neuroscience.

"It has been known for years that Alzheimer's starts in a brain region known as the entorhinal cortex," said co-senior author Scott A. Small, MD, Boris and Rose Katz Professor of Neurology, professor of radiology, and director of the Alzheimer's Disease Research Center. "But this study is the first to show in living patients that it begins specifically in the lateral entorhinal cortex, or LEC. The LEC is considered to be a gateway to the hippocampus, which plays a key role in the consolidation of long-term memory, among other functions. If the LEC is affected, other aspects of the hippocampus will also be affected."

The study also shows that, over time, Alzheimer's spreads from the LEC directly to other areas of the cerebral cortex, in particular, the parietal cortex, a brain region involved in various functions, including spatial orientation and navigation. The researchers suspect that Alzheimer's spreads "functionally," that is, by compromising the function of neurons in the LEC, which then compromises the integrity of neurons in adjoining areas.

A third major finding of the study is that LEC dysfunction occurs when changes in tau and amyloid precursor protein (APP) co-exist. "The LEC is especially vulnerable to Alzheimer's because it normally accumulates tau, which sensitizes the LEC to the accumulation of APP. Together, these two proteins damage neurons in the LEC, setting the stage for Alzheimer's," said co-senior author Karen E. Duff, PhD, professor of pathology and cell biology (in psychiatry and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at CUMC and at the New York State Psychiatric Institute.
... ... 160018.htm
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Re: Progress in learning about and fighting Alzheimer's

#2  Postby Mike_L » Jan 28, 2014 9:05 am

Possible link between Alzheimer's Disease and DDT metabolite...

Pesticide may raise risk of Alzheimer's

People with Alzheimer's disease may have higher levels of a chemical left behind by the pesticide DDT than healthy elderly people, suggested a US study out on Monday.

The pesticide, DDT, was phased out in the United States in 1972, but is still used elsewhere in the world and global health authorities consider it an important tool against malaria.

Researchers found DDE, the long-lasting metabolite of DDT, was nearly four times higher in Alzheimer's patients than in peers without the disease.

Having high DDE levels was also found to increase someone's risk of Alzheimer's fourfold, according to the study which compared 86 Alzheimer's patients to 79 people of advanced age.
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Re: Progress in learning about and fighting Alzheimer's

#3  Postby tuco » Jun 03, 2016 9:29 am

Advertising meets scientific research in new Deutsche Telekom game Sea Hero Quest

Deutsche Telekom and Saatchi & Saatchi have created Sea Hero Quest, a new mobile and online game, which is designed to provide scientific data every time it is played. This data will be used directly to aid research into dementia.

Created in collaboration with Alzheimer’s UK, UCL, the University of East Anglia, and Glitchers game developers, Sea Hero Quest is inspired by the insight that Deutsche Telekom’s 200 million users worldwide spend 3 billion hours weekly playing online and mobile games. The brand and Saatchi & Saatchi wondered if some of this time could be spent ‘gaming for good’ – where players could spend time playing a game they enjoyed but at the same time contribute useful research information.

Sea Hero Quest is designed specifically to help advance the understanding of spatial navigation, and therefore understand one of the first symptoms of dementia. Creating a global benchmark for how we navigate is widely acknowledged as one of the key steps towards developing new diagnostic tests for the diseases that cause dementia. All data collected from the game will be made freely available to scientists worldwide and will also be used by UCL: one of the world’s leading dementia research faculties, to develop new diagnostic tests for dementia. ... ero-quest/

Was just listening to professional (doctor) in the field and he said this has potential to speed up dementia research by decades.
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