Paleo Diet: Rubbish?

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Re: Paleo Diet: Rubbish?

#61  Postby wunksta » Jun 29, 2012 4:32 pm

AlohaChris wrote:
katja z wrote:I have two questions for proponents of the Paleo diet.

One is about the importance of meat and fish in the diet. How do you square this with the fact that vegetarian lifestyle is beneficial as well, specifically as far as obesity and cardiovascular diseases are concerned?


One third of people with CV disease have below normal cholesterol levels, 'healthy' height/weight ratios and exercise habits. My justification is that it's hard to maintain my muscular strength by eating plants.


katja z wrote:The other question I have is a completely practical one. Assuming the Paleo diet is the way to go, if everybody ditched grains and legumes from their diet, how do we feed the global population?


:dunno: Share the food we have better. The USA is a grain/corn/soy based agricultural economy and we're becoming the fattest nation on earth while 'spreading the wealth' to Africa and the rest of the wold.

MYPLATE.GOV. has slowly taken over for the food pyramid.  My plate is easier, I guess, to understand, but provides the same crappy food recommendations.


Ancient Grains Show Paleolithic Diet Was More Than Meat

You don't need to eliminate grains from your diet. The main thing to avoid is refined, processed grains. Look for unrefined oats/grains with few other ingredients. But of course, if you are looking to reduce weight or avoid insulin spikes or gluten, then yeah you would want to cut out excess carbs/grains.

The main point of the paleodiet, I believe, is to consume less processed foods.
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Re: Paleo Diet: Rubbish?

#62  Postby AlohaChris » Jun 29, 2012 5:16 pm

Eating the least processed foods is the goal with Paleo. Grains are avoided for two reasons:

1) Carb induced insulin spikes.
2) Gluten induced immunologic reactions in the gut. Grains are essentially grasses that evolved mechanisms (gluten) to prevent their consumption by mammals. Cows, horses and other species evolved mechanisms to digest this protective coating over the endosperm, but humans lack this mechanism.
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Re: Paleo Diet: Rubbish?

#63  Postby Warren Dew » Jun 29, 2012 6:19 pm

AlohaChris wrote:Gluten induced immunologic reactions in the gut. Grains are essentially grasses that evolved mechanisms (gluten) to prevent their consumption by mammals. Cows, horses and other species evolved mechanisms to digest this protective coating over the endosperm, but humans lack this mechanism.

Correct. Whole grains are just as bad as processed grains in this respect.
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Re: Paleo Diet: Rubbish?

#64  Postby wunksta » Jun 29, 2012 6:35 pm

AlohaChris wrote:Eating the least processed foods is the goal with Paleo. Grains are avoided for two reasons:

1) Carb induced insulin spikes.
2) Gluten induced immunologic reactions in the gut. Grains are essentially grasses that evolved mechanisms (gluten) to prevent their consumption by mammals. Cows, horses and other species evolved mechanisms to digest this protective coating over the endosperm, but humans lack this mechanism.


Warren Dew wrote:
AlohaChris wrote:Gluten induced immunologic reactions in the gut. Grains are essentially grasses that evolved mechanisms (gluten) to prevent their consumption by mammals. Cows, horses and other species evolved mechanisms to digest this protective coating over the endosperm, but humans lack this mechanism.

Correct. Whole grains are just as bad as processed grains in this respect.


As evidenced above, grains were eaten by humans historically. If someone has a problem with gluten, they can avoid it and still eat grain. Not all grains are bad in that regard, afaik.

Furthermore, it's estimated that only 10% of the population have gluten intolerance, so why should everyone follow a diet that is based around that?
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Re: Paleo Diet: Rubbish?

#65  Postby Pebble » Jun 29, 2012 7:23 pm

Elena wrote:
This diet consistently reduces:
- cardiovascular disease, including high blood pressure
- diabetes type 2
- excess weight
- chronic inflammatory diseases :


This is correlation not causation. While any diet that reduces the excess of carbohydrates and salt currently consumed seems sensible, few randomised trials have been completed, very few with clinical outcomes such as the above, and none can be double blind. So the diet is associated with changes in blood chemistry that is predicted to reduce cardiovascular disease, is closer to the mark.

Don't want to make a meal out of this, but the purveyors of all food fads gloss over this important distinction and when the next fad comes along claims that have not panned out are used to discredit previous alternatives.
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Re: Paleo Diet: Rubbish?

#66  Postby Warren Dew » Jun 29, 2012 11:11 pm

wunksta wrote:As evidenced above, grains were eaten by humans historically.

While the article makes it sound that way, the paper proves much less. Grasses were processed by humans for some unknown purpose 30,000 years ago, yes. They might have been eaten; they might not have. Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.

Furthermore, it's estimated that only 10% of the population have gluten intolerance, so why should everyone follow a diet that is based around that?

I'm not trying to convince people to follow the paleo diet. If people want to eat grains as their primary calorie source, that leaves more of the good food for me.

Pebble wrote:
Elena wrote:
This diet consistently reduces:
- cardiovascular disease, including high blood pressure
- diabetes type 2
- excess weight
- chronic inflammatory diseases :

This is correlation not causation.

Causations have been looked at for related diets, and other low carb diets have been shown to result in reduced weight in randomized controlled trials:

http://jama.jamanetwork.com/article.asp ... eid=205916
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Re: Paleo Diet: Rubbish?

#67  Postby wunksta » Jun 30, 2012 2:05 am

Warren Dew wrote:
wunksta wrote:As evidenced above, grains were eaten by humans historically.

While the article makes it sound that way, the paper proves much less. Grasses were processed by humans for some unknown purpose 30,000 years ago, yes. They might have been eaten; they might not have. Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.


What are you basing that assumption on? We have only been been drinking milk from other animals for the past few thousand years afaik, and we have evolved to adapt to that, with the majority of the population developing lactose tolerance. Humans didn't start out that way, so we had to evolve and adapt for it.

I would assume this holds true for gluten tolerance, especially considering that the majority of the population can handle it now. Which leads me to believe that we have had enough time to fully adapt to the change. I would be open to any insight you could provide on this though.

Obviously, the ability for our bodies to consume and digest it does not mean that it's healthy for us but I guess we need to determine what we mean by 'adapt'.


Furthermore, it's estimated that only 10% of the population have gluten intolerance, so why should everyone follow a diet that is based around that?

I'm not trying to convince people to follow the paleo diet. If people want to eat grains as their primary calorie source, that leaves more of the good food for me.


Gotcha. I guess I was just confused on what your point of demonizing grains was. "It's bad for you" kind of makes it sound like you are trying to encourage or enlighten people on detrimental dietary habits, but if I'm mistaken I apologize.
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Re: Paleo Diet: Rubbish?

#68  Postby AlohaChris » Jun 30, 2012 2:12 am

Just because you can eat grains, doesn't mean it's benign. 10% of the public having gluten intolerance - I'll accept that, but that 10% is likely having a severe enough allergic reaction to notice immediately.

I did the 30 day paleo challenge and avoided all grains and processed foods. Then I did as suggested and went back to eating grains again - and immediately felt sick. Gas, bloating and unpleasant changes in bowel habits. It was enough to convince me. When I eliminated the grains from my diet again, these unpleasant changes all reversed themselves. My gut is much happier.

It's been postulated that many gut problems such as Celiac's disease, Irritable Bowel Syndrome and Chronic Colitis may be related to our consumption of grains and the chronic upregulation of the immune system related to antigens presented by grains.
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Re: Paleo Diet: Rubbish?

#69  Postby AlohaChris » Jun 30, 2012 2:34 am

wunksta wrote:Gotcha. I guess I was just confused on what your point of demonizing grains was. "It's bad for you" kind of makes it sound like you are trying to encourage or enlighten people on detrimental dietary habits, but if I'm mistaken I apologize.


I'll take that position. :grin:

A wealth of scientific literature exists to support the concept that grains & legumes are potentially detrimental to health.

Plants have evolved three major strategies to resist predation so that their reproductive material (seeds) can survive to reproduce. These three mechanisms are: 1) toxic compounds to discourage predation, 2) structural barriers to predation such as spikes and thorns (as found in cactus) or hard shells (such as coconuts), and 3) a sweet outer layer (fruit) that encourages consumption, combined with hard, small seeds within the fruit that are impervious to the enzymes in the digestive tract of the predator and can pass through into the feces which spread the seed along with free fertilizer.

Cereal grains (wheat, rye, barley, oats, corn, rice, etc) and legumes (beans, lentils, peas, peanuts etc.) have evolved toxic compounds to prevent predation. These anti-nutritional compounds include lectins, saponins, protease inhibitors, phytate, thaumatin like proteins, alkylresorcinols, and others whose effects range from lethal toxicity to benign depending upon the antinutrient and the species of predator. In humans, exposure to these toxins manifest as auto-immune disorders, inflammatory disease, Celiac's disease, non-celiac gluten intolerance (NCGI), Type II diabetes, and vitamin deficiencies.

Source: http://thepaleodiet.com/published-research

Cordain L, Toohey L, Smith MJ, Hickey MS. Modulation of immune function by dietary lectins in rheumatoid arthritis. British Journal of Nutrition, 2000, 83:207-217.

[Reveal] Spoiler: Abstract
Abstract: Despite the almost universal clinical observation that inflammation of the gut is frequently associated with inflammation of the joints and vice versa, the nature of this relationship remains elusive. In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. In genetically susceptible individuals, this antigenic stimulation may ultimately result in the expression of overt rheumatoid arthritis (RA) via molecular mimicry, a process whereby foreign peptides, similar in structure to endogenous peptides, may cause antibodies or T- lymphocytes to cross-react with both foreign and endogenous peptides and thereby break immunological tolerance. By eliminating dietary elements, particularly lectins, which adversely influence both enterocyte and lymphocyte structure and function, it is proposed that the peripheral antigenic stimulus (both pathogenic and dietary) will be reduced and thereby result in a diminution of disease symptoms in certain patients with RA.


Link to download PDF of paper.

Sapone, A., et al., Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Medicine, 2011. 9(23).


[Reveal] Spoiler: Abstract
Background
Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Gluten-sensitive individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD, but the overall clinical picture is generally less severe and is not accompanied by the concurrence of tissue transglutaminase autoantibodies or autoimmune comorbidities. By studying and comparing mucosal expression of genes associated with intestinal barrier function, as well as innate and adaptive immunity in CD compared with GS, we sought to better understand the similarities and differences between these two gluten-associated disorders.

Methods
CD, GS and healthy, gluten-tolerant individuals were enrolled in this study. Intestinal permeability was evaluated using a lactulose and mannitol probe, and mucosal biopsy specimens were collected to study the expression of genes involved in barrier function and immunity.

Results
Unlike CD, GS is not associated with increased intestinal permeability. In fact, this was significantly reduced in GS compared with controls (P = 0.0308), paralleled by significantly increased expression of claudin (CLDN) 4 (P = 0.0286). Relative to controls, adaptive immunity markers interleukin (IL)-6 (P = 0.0124) and IL-21 (P = 0.0572) were expressed at higher levels in CD but not in GS, while expression of the innate immunity marker Toll-like receptor (TLR) 2 was increased in GS but not in CD (P = 0.0295). Finally, expression of the T-regulatory cell marker FOXP3 was significantly reduced in GS relative to controls (P = 0.0325) and CD patients (P = 0.0293).

Conclusions
This study shows that the two gluten-associated disorders, CD and GS, are different clinical entities, and it contributes to the characterization of GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
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Re: Paleo Diet: Rubbish?

#70  Postby Warren Dew » Jun 30, 2012 3:44 am

wunksta wrote:
Warren Dew wrote:
wunksta wrote:As evidenced above, grains were eaten by humans historically.

While the article makes it sound that way, the paper proves much less. Grasses were processed by humans for some unknown purpose 30,000 years ago, yes. They might have been eaten; they might not have. Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.


What are you basing that assumption on? We have only been been drinking milk from other animals for the past few thousand years afaik, and we have evolved to adapt to that, with the majority of the population developing lactose tolerance. Humans didn't start out that way, so we had to evolve and adapt for it.

I would assume this holds true for gluten tolerance, especially considering that the majority of the population can handle it now. Which leads me to believe that we have had enough time to fully adapt to the change. I would be open to any insight you could provide on this though.

Obviously, the ability for our bodies to consume and digest it does not mean that it's healthy for us but I guess we need to determine what we mean by 'adapt'.

This is why I said "fully adapt" rather than just "adapt". Some people can digest milk sugar, true, but that doesn't mean that bovine casein doesn't cause an inflammatory response similar to gluten.

As for how I reach my conclusion, it's from looking at two factors:

- Ability to obtain energy is one of the strongest evolutionary selectors, probably an order of magnitude stronger than effects like inflammation. One would therefore expect the degree of adaptation to new energy sources like dairy lactose and grain starches would be much stronger than to other factors like inflammatory or otherwise deleterious components of plant or milk protein.

- Even this strong selection pressure for digestion of lactose and starch has only managed to drive mutations of the simplest and most common types. Adult lactose tolerance relies on disabling of a regulator region for the lactase gene which can happen though any point mutation in a region hundreds of base pairs in length; no new genetic functionality, which would take far longer to develop, is required. Likewise, the increased amylase copy number that is found in long term agricultural populations results from routine genetic recombination during meiosis, and doesn't even require a single nucleotide change. Despite how easily these mutations can occur, neither has been driven to fixation.

Given the highly important energy content in dairy and starchy agricultural products has only resulted in very limited adaptation in 10,000-30,000 years, the lower selection pressure from allergens and other low level poisons should not be expected to have resulted in any noticeable adaptation at all within the same period of time. Even slightly more sophisticated mutations, like the FOXP2 mutation in humans and neanderthals, appear to take hundreds of thousands of years to occur and become common.

I'm not trying to convince people to follow the paleo diet. If people want to eat grains as their primary calorie source, that leaves more of the good food for me.

Gotcha. I guess I was just confused on what your point of demonizing grains was. "It's bad for you" kind of makes it sound like you are trying to encourage or enlighten people on detrimental dietary habits, but if I'm mistaken I apologize.

I'm a libertarian; I have no problem with people doing detrimental things to themselves if they want.
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Re: Paleo Diet: Rubbish?

#71  Postby Spearthrower » Jun 30, 2012 3:53 am

Warren Dew wrote:Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.



On what basis does this claim rest?
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Re: Paleo Diet: Rubbish?

#72  Postby Spearthrower » Jun 30, 2012 3:55 am

AlohaChris wrote:
It's been postulated that many gut problems such as Celiac's disease, Irritable Bowel Syndrome and Chronic Colitis may be related to our consumption of grains and the chronic upregulation of the immune system related to antigens presented by grains.


To add my anecdote - a few years after moving to Thailand, I developed something like IBS. However, my consumption of grains since I've lived here has dropped to a tiny fraction of the amount I'd be eating if I were still in the UK.
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Re: Paleo Diet: Rubbish?

#73  Postby wunksta » Jun 30, 2012 4:21 am

AlohaChris wrote:

Cereal grains (wheat, rye, barley, oats, corn, rice, etc) and legumes (beans, lentils, peas, peanuts etc.) have evolved toxic compounds to prevent predation. These anti-nutritional compounds include lectins, saponins, protease inhibitors, phytate, thaumatin like proteins, alkylresorcinols, and others whose effects range from lethal toxicity to benign depending upon the antinutrient and the species of predator. In humans, exposure to these toxins manifest as auto-immune disorders, inflammatory disease, Celiac's disease, non-celiac gluten intolerance (NCGI), Type II diabetes, and vitamin deficiencies.


I may not be understanding everything, but the articles you listed seem to indicate, to me at least, that these are problems for people who are genetically susceptible to these kinds of things in the first place.

If one is not genetically at risk for these kinds of things, then why should one avoid cereal grains or legumes? Secondly, and correct me if I am wrong, I don't see anything indicating that gluten free wheat would be a problem, other than increased carbs and insulin issues.
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Re: Paleo Diet: Rubbish?

#74  Postby Warren Dew » Jun 30, 2012 4:25 am

Spearthrower wrote:
Warren Dew wrote:Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.

On what basis does this claim rest?

Check the post above yours, where I answered a similar question from wunksta.
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Re: Paleo Diet: Rubbish?

#75  Postby AlohaChris » Jun 30, 2012 4:35 am

wunksta wrote:
AlohaChris wrote:

Cereal grains (wheat, rye, barley, oats, corn, rice, etc) and legumes (beans, lentils, peas, peanuts etc.) have evolved toxic compounds to prevent predation. These anti-nutritional compounds include lectins, saponins, protease inhibitors, phytate, thaumatin like proteins, alkylresorcinols, and others whose effects range from lethal toxicity to benign depending upon the antinutrient and the species of predator. In humans, exposure to these toxins manifest as auto-immune disorders, inflammatory disease, Celiac's disease, non-celiac gluten intolerance (NCGI), Type II diabetes, and vitamin deficiencies.


I may not be understanding everything, but the articles you listed seem to indicate, to me at least, that these are problems for people who are genetically susceptible to these kinds of things in the first place.

If one is not genetically at risk for these kinds of things, then why should one avoid cereal grains or legumes? Secondly, and correct me if I am wrong, I don't see anything indicating that gluten free wheat would be a problem, other than increased carbs and insulin issues.


I'll reply more in depth tomorrow, but in short it isn't just the gluten. It also the other anti-nutrient compounds that can block vitamin absorption and promote inflammation. You don't have to be genetically susceptible to suffer these effects.
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Re: Paleo Diet: Rubbish?

#76  Postby Spearthrower » Jun 30, 2012 4:35 am

Warren Dew wrote:
Spearthrower wrote:
Warren Dew wrote:Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.

On what basis does this claim rest?

Check the post above yours, where I answered a similar question from wunksta.


I have read the post above, and still don't see a basis for the claim. Some other mutations take longer to become fixed, therefore we haven't had time to adapt to a change in diet regarding grains. That doesn't appear to be much of an argument let alone a foundation for the claim.
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Re: Paleo Diet: Rubbish?

#77  Postby Pebble » Jun 30, 2012 11:41 am

Warren Dew wrote:
Pebble wrote:
Elena wrote:
This diet consistently reduces:
- cardiovascular disease, including high blood pressure
- diabetes type 2
- excess weight
- chronic inflammatory diseases :

This is correlation not causation.

Causations have been looked at for related diets, and other low carb diets have been shown to result in reduced weight in randomized controlled trials:

http://jama.jamanetwork.com/article.asp ... eid=205916


So?

This is only tangentially related to the paleo fad, and has nothing to do with the clinical outcome I challenged! The association between excessive carbohydrate and weight gain is increasingly strongly supported there is also strong support for carb-diabetes association, but that does not lend support to the paleo philosophy - merely shows that our homeostatic weight balance is confounded by a very high carb intake.
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Re: Paleo Diet: Rubbish?

#78  Postby Warren Dew » Jul 01, 2012 11:58 pm

Pebble wrote:
Warren Dew wrote:
Pebble wrote:
Elena wrote:
This diet consistently reduces:
- cardiovascular disease, including high blood pressure
- diabetes type 2
- excess weight
- chronic inflammatory diseases :

This is correlation not causation.

Causations have been looked at for related diets, and other low carb diets have been shown to result in reduced weight in randomized controlled trials:

http://jama.jamanetwork.com/article.asp ... eid=205916

So?

This is only tangentially related to the paleo fad, and has nothing to do with the clinical outcome I challenged! The association between excessive carbohydrate and weight gain is increasingly strongly supported there is also strong support for carb-diabetes association, but that does not lend support to the paleo philosophy - merely shows that our homeostatic weight balance is confounded by a very high carb intake.

From the standpoint of macronutrient intake, paleo is very similar to the version of Atkins tested in that trial. The main differences are in specific foods, as paleo permits fresh whole fruit, which is prohibited on Atkins during the induction period.

If you want to argue that paleo is a worse diet than Atkins because it permits fruit, feel free, but I'm not going to agree with you.
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Re: Paleo Diet: Rubbish?

#79  Postby Warren Dew » Jul 02, 2012 1:25 am

Spearthrower wrote:
Warren Dew wrote:
Spearthrower wrote:
Warren Dew wrote:Even if they were eaten, 30,000 years ago was at the end of the 2,000,000 year paleolithic period, so we wouldn't have had enough time to fully adapt to the change in diet.

On what basis does this claim rest?

Check the post above yours, where I answered a similar question from wunksta.

I have read the post above, and still don't see a basis for the claim. Some other mutations take longer to become fixed, therefore we haven't had time to adapt to a change in diet regarding grains. That doesn't appear to be much of an argument let alone a foundation for the claim.

Granted you may need to familiarize yourself with the concepts of selection pressure, single nucleotide mutation rates, and chromosomal recombination to understand my explanation.
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Re: Paleo Diet: Rubbish?

#80  Postby Spearthrower » Jul 02, 2012 7:36 am

Warren Dew wrote:
Spearthrower wrote:
Warren Dew wrote:
Spearthrower wrote:
On what basis does this claim rest?

Check the post above yours, where I answered a similar question from wunksta.

I have read the post above, and still don't see a basis for the claim. Some other mutations take longer to become fixed, therefore we haven't had time to adapt to a change in diet regarding grains. That doesn't appear to be much of an argument let alone a foundation for the claim.

Granted you may need to familiarize yourself with the concepts of selection pressure, single nucleotide mutation rates, and chromosomal recombination to understand my explanation.



Possibly... or you might need to provide some substance supporting your claim. Either might work.
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