Perhaps the main negatives associated with sugar are...
a) its high calorie density.... i.e. relatively small volumes of sugar deliver plenty of calories.
b) sugar is opioidergic and dopaminergic.... i.e. significantly stimulates the pleasure-reward centres of the brain, hence the phenomenon of "
sugar addiction".
a + b = elevated risk of obesity
Of course the above is a generalisation that doesn't take into account other factors.... genetics, level of physical activity, other dietary components, etc. But, for the most part, a high intake of sugar-rich foods will predispose a person to weight gain.
Complicating matters is the fact that sugar-rich foods don't always
taste sweet. Sugar is frequently used to "balance out" spicy (capsaicin), sour or bitter tastes in processed foods.... e.g. sugar is frequently first
* in the ingredients listing of ketchup, chilli sauce, etc.
(
*)
Labelling laws require that ingredients be listed in decreasing order of their contribution (by mass).As for the (controversial, disputed) link between sugar and hyperactivity through its effect on blood sugar, adrenal stimulation, etc....
IF such a link exists in some individuals, then it may be possible to ameliorate it simply by ensuring that the sugar-rich food is not eaten on an empty stomach. The simultaneous presence of other macronutrients (proteins and fats) in the stomach tends to reduce the effective glycaemic index of a carbohydrate-rich food, because the proteins and fats slow the passage of stomach contents to the small intestine (where most of the absorption into the bloodstream occurs). So a dessert eaten after a proper meal will theoretically have a less pronounced effect on blood sugar than will a candy bar or fizzy drink consumed an hour-or-so before a meal.
All things considered, I'd still choose sugar (in moderation) over aspartame, saccharin, acesulfame K, cyclamate, etc.