Federico wrote:Epigenetic mechanisms would be up- or down-regulated by the presence or absence of a culture which puts a premium on music playing.
Mr.Samsa wrote:.
This part is the problem. You haven't presented any evidence that this is possible and you seem to be basing your belief in this on your failure to understand epigenetics.
The environment in epigenetics does not include learning and culture. Certain aspects of our culture might make epigenetic changes more likely, for example if we lived in a mining culture then presumably certain chemicals or hormonal changes from spending most of our lives at the bottom of a coal mine would have some physiological effects, and some of these epigenetic changes might possibly be inheritable. But your understanding of epigenetics is crazy...
Federico wrote:IOW, stem cells have acquired during evolution all the paraphernalia essential for regulating the 20.000-30,000 genes of the human genome. But when they differentiate into Insulin-producing cells in the Pancreas, or into music-producing neurones in the brain, they will respond only to some specific signals such as changes in blood sugar levels and changes in mood(?), respectively.
How does mood influence the neurones which will make you sing or play the violin? This is still the $ 40,000 question, but certainly hormones and neurotransmitters are major players in this field.
Mr.Samsa wrote:That's nice, but it has nothing to do with epigenetics.
OK, Mr.Samsa: At least we have succeeded in exactly identifying where is the bone. Therefore, I'll try a different approach starting first with what you accept.
The capacity to make musical sounds orally was an evolutionary event which occurred in prehistoric men before talk. It must have given an evolutionary advantage such as for mating (mating calls), and for transmitting information and bonding within a tribe. It was the result of random mutations of primordial genes present in the brain, resulting in neurones differentiated for the production of musical sounds. This capacity was shared with birds and humpback whales, and preceded talk, which is also the result of genes' mutations but not only in the brain, since the larynx had to change to become a word-producing organ. This capacity is restricted to humans.
This capacity to make, but also to enjoy, musical sounds orally first, then through more and more sophisticated and pleasant to listen to instruments, was and still is under the control of specifically differentiated brain neurones which not only contain genes for music like all body cells, but also, and uniquely, the epigenetic machinery necessary for turning on and off the genes.
Now, for a more daring leap of faith, I will call music "
Food for the Soul". As a learned person as you are, I'm sure you have already heard this aphorism. It was also used by
Shakespeare, who once said: "If music is food for love, lets play on." Therefore, in order to better understand the interplay of genes and epigenetic mechanisms which can be modified by the environment, I will compare the brain to the gut (which, BTW, is considered as a brain equivalent), musical genes with their machinery to enzyme-producing enterocytes, and music to food such as lactose.
As I have written above, making music evolved from a rudimentary, life saving tool, to a more and more sophisticated and pleasure-giving talent. For this, the machinery had to evolve and become more attuned to environmental needs, which is what occurred in the Middle Ages when European Courts required and had much respect for
Minstrels, many of whom were Jewish, since music-making and money-lending were the only activities they were allowed to do.
Thus, environmental pressure made for the selection of the best, perfect pitch, musicians, and the potential transmission to the offspring of this talent.
Lets get back to the gut or little brain.
As a well read person, Mr.Samsa, I'm sure you have heard of the History of
Lactase Deficiency.
Just to make a long story short, lactase is an enzyme made by enterocytes and which digests lactose, a milk sugar.
The gene for lactase and the regulating machinery appeared in prehistoric times by the usual evolutionary rules. However, at a certain point in time, sub-Sahara Africans lost the capacity to produce lactase, probably because milk had disappeared , and the machinery stopped operating. On the contrary, Northern Europeans were and still are blessed with large amounts of milk and milk produces, which they digest very well since their gut never stopped producing lactase.
Nowadays, many Africans and Afro-Americans still lack lactase and get sick if exposed to milk.
To conclude, music is food for the soul without which many people would find life much less enjoyable. To produce good music you need music neurones endowed with a well functioning machinery inherited from ancestors who were selected by environmental pressures for their musical proficiency.
In the End, we will remember not the words of our enemies, but the silence of our friends.(Martin Luther King Jr)