Marijuana appreciation/education/information thread

[trubble76]

Poll: Nationwide marijuana legalization inevitable (USA)

Associated Press= DENVER (AP) — Nationwide marijuana legalization seems inevitable to three-fourths of Americans, whether they support it or not.

That's according to a new poll out Wednesday by the Pew Research Center on the nation's shifting attitudes about drug policy.

Continues here.

[Kenaz]

I'll just leave this here.

"Cannabis Use is Quantitatively Associated with Nucleus
Accumbens and Amygdala Abnormalities in Young Adult
Recreational Users"
http://jn.sfn.org/press/April-16-2014-I ... 005529.pdf

[willhud9]

In other news: Abuse of a substance can lead to issues with the body.

[hackenslash]

Which substance?

Edit: And what constitutes abuse?

[tuco]

I'll just leave this here.

"Cannabis Use is Quantitatively Associated with Nucleus
Accumbens and Amygdala Abnormalities in Young Adult
Recreational Users"
http://jn.sfn.org/press/April-16-2014-I ... 005529.pdf

Both gray matter density and average volume were increased in marijuana participants in the left nucleus accumbens.

Is this good or bad?

[BlackBart]

Edit: And what constitutes abuse?

Not giving me any.

[Adco]

Tonight Mmmmm Just appreciating

[andyx1205]

That's a blunt of some killer stuff from British Columbia.

[Tangerine Dream]

Which substance?

Edit: And what constitutes abuse?

You tell me ! Absolutely agree all the way ! As far as I can remember I've never abused any substance whatsoever

[Tangerine Dream]

http://www.thecannabist.co/2014/04/17/w ... lumn/9571/

[Kenaz]

Portable vaporizers are a miracle. So much healthier, potent, and tasty. At least that's what I hear.

[The_Piper]

I have the magic flight launch box. It basically sucks. When it still worked good, it would irritate my lips and throat. Same thing happened using the Easyvape desktop model. Now I have an arizer bag & whip vape and it's still harsh on my throat towards the end of the bowl. I want to believe in vaporizers, but they haven't been too helpful to me yet. "It's not them, it's me", I have a very sensitive throat.

[Adco]

The fire is sublime

[DoctorE]

....

[DoctorE]

[Tangerine Dream]

[theropod]

LINK to abstract.

"Histone modifications are associated with Delta(9)-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses"

Xiaoming Yang, Venkatesh L. Hegde, Roshni Rao, Jiajia Zhang, Prakash S. Nagarkatti and Mitzi Nagarkatti

The Journal of Biological Chemistry
doi: 10.1074/jbc.M113.545210

Marijuana is one of the most abused drugs due to its psychotropic effects. Interestingly, it is also used for medicinal purposes. The main psychotropic component in marijuana, Δ9-tetrahydrocannabinol (THC), has also been shown to mediate potent anti-inflammatory properties. Whether the immunomodulatory activity of THC is mediated by epigenetic regulation has not been investigated previously. In this study, we employed ChIP-Seq technology to examine the in vivo effect of THC on global histone methylation in lymph node cells of mice immunized with a superantigen, staphylococcal enterotoxin B (SEB). We compared genome-wide histone H3K4, H3K27, H3K9, H3K36 trimethylation and H3K9 acetylation patterns in such cells exposed to THC or vehicle. Our results showed that THC treatment leads to the association of active histone modification signals to Th2 cytokine genes and suppressive modification signals to Th1 cytokine genes, indicating that such a mechanism may play a critical role in THC-mediated switch from Th1 to Th2. At the global level, a significant portion of histone methylation and acetylation regions were altered by THC. However, the overall distribution of these histone methylation signals among the genomic features were not altered significantly by THC, suggesting that THC activates the expression of a subset of genes while suppressing the expression of another subset of genes through histone modification. Functional classification of these histone marker associated genes showed that these differentially associated genes were involved in various cellular functions, from cell cycle regulation to metabolism, suggesting that THC had a pleiotropic effect on gene expression in immune cells. Together, the current study demonstrates for the first time that THC may modulate immune response through epigenetic regulation involving histone modifications.

Thoughts?

RS

[The_Piper]

Is that good or bad? It's written in Chinese and Latin.

[CdesignProponentsist]

I'll just leave this here.

"Cannabis Use is Quantitatively Associated with Nucleus
Accumbens and Amygdala Abnormalities in Young Adult
Recreational Users"
http://jn.sfn.org/press/April-16-2014-I ... 005529.pdf

Should we ban from adults everything that is bad for teens or should we not live in a nanny state?

[Kenaz]

I am not advocating the restriction or nanny state, whatsoever. I do like to throw stuff out there that challenges my views or stances, however. That is what I was intending by posting that data here. I am very much pro-education, pro-choice, self-responsibility minded when it comes to most things, including recreational drug use.